Welcome to the Le lab!
We are at the interface of medicinal chemistry and enzymology.
Welcome to the Le lab!
We are at the interface of medicinal chemistry and enzymology.
About Us
We are a medicinal chemistry research group in the Department of BioMolecular Sciences at the University of Mississippi School of Pharmacy. We have broad interests and expertise in many topics related to drug discovery and development, including organic synthesis, methodology, structure-based drug design, structure-activity relationship, and enzymology. We use organic synthesis and computational modeling as primary tools to design and synthesize potential therapeutic agents and collaborate with other research groups to evaluate their biological activities and investigate their molecular mechanisms of action.
Recent News
- September 28, 2022: Tristan and Seth received funding from the Honors College for their Honors thesis research projects. Congratulations, Tristan and Seth!
- September 19, 2022: Imdad received an offer for a postdoctoral position in the Gryder and Stauffer labs (joint position) at Case Western Reserve University School of Medicine and Cleveland Clinic. Congratulations, Imdad!
- September 16, 2022: Our latest manuscript was accepted for publication at European Journal of Medicinal Chemistry. Congratulations, Imdad, Ben, and Nick!
- September 5, 2022: Our latest manuscript was accepted and published at Chemistry and Biodiversity. Congratulations, Ayoub!
- August 19, 2022: The Office of Technology Commercialization filed an international/U.S. patent application for our collaborative work with the Paris lab on allopregnanolone analogues for HIV viremia and neurotoxicity protection.
- July 23 - 27, 2022: Imdadul Khan and Ben Sawyer presented our lab's research at the AACP's annual meeting in Grapevine, Texas.
- July 9, 2022: We published an invited editorial with our collaborators at UPenn at Translational Perioperative and Pain Medicine.
- May 31, 2022: Zeyad Ibrahim joined us as a student in the ARISE program. Welcome, Zeyad!
- May 20 - 22, 2022: Hoang attended the 2022 ACS Leadership Institute.
- May 18 - 20, 2022: Hoang served as an oral and poster presentation judge, and Imdadul Khan and Ben Sawyer presented our lab's research at the 2022 MALTO Medicinal Chemistry and Pharmacognosy Meeting-in-Miniature. Imdadul won the Thomas L. Lemke Outstanding Poster Presentation Award. Congratulations, Imdadul!
- May 7, 2022: Leo Yang graduated with a B.S. degree in Pharmaceutical Sciences. Congratulations, Leo!
- April 29, 2022: Ben Sawyer was elected President of BioMolecular Sciences Student Advocates. Congratulations, Ben!
- April 25, 2022: Hoang gave an invited lecture at Northwestern University.
- April 19, 2022: Md Imdadul Khan won an ACS Graduate Research Scholar Award, and Leo Yang won an ACS Undergraduate Research Scholar Award. Congratulations, Imdad and Leo!
- April 12, 2022: Hoang served as a Poster Abstract Reviewer for the 2022 AACP Annual Meeting.
- April 7, 2022: Ben Sawyer successfully defended his original research proposal (ORP) and has advanced to Ph.D. candidacy. Congratulations, Ben!
- April 1, 2022: Leo Yang won the SOP's Distinguished Citation for Outstanding Contributions to the Research Mission of BioMolecular Sciences, and Tristan Tran won the SOP's Helping Hands Award. Congratulations, Leo and Tristan!
- March 11, 2022: Our manuscript on the synthesis of 3,4,5-trisubstituted isoxazoles in water was accepted by Beilstein Journal of Organic Chemistry. Congratulations, Imran, Imdad, and Seong Jong!
- February 24, 2022: Seth McCaughan joined our lab as an undergrad researcher. Welcome, Seth!
- February 15, 2022: We submitted our very first book chapter, Chapter 11 Antimalarial Drugs, for the book Medicinal Chemistry of Chemotherapeutic Agents, edited by Pratap Acharya and Michio Kurosu, published by Elsevier/Academic Press with the anticipated publication date of September 1, 2022. The book can be preordered on the Elsevier website here: https://www.elsevier.com/books/medicinal-chemistry-of-chemotherapeutic-agents/acharya/978-0-323-90575-6
Congratulations, Ben and Imdad!
- January 12, 2022: Hoang served as a reviewer for the NSF Graduate Research Fellowships Program (GRFP).
- January 7, 2022: Our paper on salvinorin dual kappa and mu opioid receptor agonists was accepted to ChemMedChem. Congratulations, Nick!
- November 19, 2021: Hoang was selected for the National Research Mentoring Network (NRMN)'s Grant Writing Coaching program.
- November 18, 2021: Imdadul Khan passed his prospectus. Congratulations, Imdadul!
- November 17, 2021: Hoang was elected Chair-Elect of the American Chemical Society Local Section at the University of Mississippi.
- November 16, 2021: Hoang was asked to serve on the 2022 AACP Chemistry Section Awards Committee.
- November 8, 2021: Hoang served as a reviewer for the NSF SBIR/STTR program.
- October 29, 2021: The Research Topic "Targeting Cancer Metabolic Reprogramming for Cancer Therapy" (Hoang is the Topic Editor) in Frontiers in Drug Discovery is now open for submission.
- October 3, 2021: Our collaborative review paper got published in the Journal of Neuroendocrinology. Congratulations, Nick!
- August 30, 2021: Matthew Bee joined our lab as an undergrad researcher. Welcome, Matthew!
- August 22-26, 2021: Hoang gave an oral presentation; Imdadul and Ben gave poster presentations on our research at the ACS National Meeting in Atlanta, GA. Well done, Imdadul and Ben!
- August 12, 2021: Hoang served as a reviewer for the NSF SBIR/STTR program.
- August 2, 2021: Hoang was appointed as an Associate Editor of the journal Frontiers in Drug Discovery.
- July 7, 2021: Our collaborative paper got published on Molecules.
- June 22, 2021: Tristan Tran joined our lab as an undergrad researcher. Welcome, Tristan!
- May 24, 2021: Jiaxin (Leo) Yang joined our lab as an undergrad researcher. Welcome, Leo!
- April 29, 2021: Nick Akins graduated with a Ph.D. in Pharmaceutical Sciences. He is starting his postdoctoral work with Dr. Dennis Liotta at Emory University in May. Congratulations, Nick!
- April 27, 2021: Ben Sawyer received a GSC Research Grant for his project "Synthesis and Assessment of Potential Carbazole-based Antimalarials". Congratulations, Ben!
Contact Us
Hoang V. Le, Ph.D.
Department of BioMolecular Sciences
The University of Mississippi School of Pharmacy
419 Faser Hall
University, MS 38677
Phone: (662) 915-2555
Email: hle@olemiss.edu