Hoang Le Research Group

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Hoang Le Research Group

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  • Hoang Le
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  • Funding

Hoang V. Le

Positions Held

2016–Present:  Assistant Professor of Medicinal Chemistry, Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi


2016–Present:  Research Assistant Professor, Research Institute of Pharmaceutical Sciences
School of Pharmacy, University of Mississippi


​2020–Present:  Member, UMMC Cancer Center and Research Institute


2019–2021:  Graduate Program Coordinator, Medicinal Chemistry Division, Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi


2018–2019:  Visiting Scientist, St. Jude Children's Research Hospital

Education

Postdoctoral Researcher, Northwestern University (2013 - 2016). Advisor: Richard Silverman


Ph.D., Cornell University, 2013. Advisor: Bruce Ganem


B.S., University of California, Berkeley, 2008. Advisor: Kenneth Raymond

Honors and Awards

2021:  P2 Teaching Team of the Year Award (Team Member), UM School of Pharmacy


2020:  P1 Teaching Team of the Year Award (Team Leader), UM School of Pharmacy


2018:  New Investigator Award, American Association of Colleges of Pharmacy (AACP)


​2010–2012:   NIH Chemistry/Biology Interface Training Grant

Pharmaceutical Invention

Co-inventor of OV329, licensed to OVID Therapeutics 2016-Present 

Industrial Experience

10/2011­–11/2011:  ​Avila Therapeutics, Inc. (now part of Bristol Myers Squibb)

Editorial Board

2021–2022:  Topic Editor, "Targeting Cancer Metabolic Reprogramming for Cancer Therapy", Frontiers in Drug Discovery 


2021–Present:  Associate Editor, Frontiers in Drug Discovery 

Grant Reviewing Experiences

2022:  Reviewer, NSF Graduate Research Fellowships Program (GRFP)


2021:  Reviewer, NSF SBIR/STTR program


2021:  Reviewer, NSF Graduate Research Fellowships Program (GRFP)


​2020:  Reviewer, NSF Graduate Research Fellowships Program (GRFP)


2019:  Reviewer, NSF Graduate Research Fellowships Program (GRFP)


2018:  Reviewer, Innovational Research Incentive Scheme – Veni Programme


2017:  Reviewer, NIH Macromolecular Structure and Function A Study Section


2017:  NIH Early Career Reviewer Program

Leadership Experiences

2022:  ACS Leadership Institute


2022:  Member, AACP Chemistry Section Awards Committee 


2021–2022:  Chair-Elect, American Chemical Society Local Section, University of Mississippi 


2021–2022:  Vice Chair, Research and Graduate Affairs Committee, School of Pharmacy, University of Mississippi 


2021–Present:  Member, UM Mentoring Working Group 


2021–Present:  Member, UM Graduate School's Graduate Student Mental Health and Well-being Advisory Board


2021:  Member, AACP Chemistry Section Awards Committee


2018–2021:  Secretary (elected in 2018; re-elected in 2019 and 2020), American Chemical Society Local Section, University of Mississippi


​2020–2021:  Vice Chair, Research and Graduate Affairs Committee, School of Pharmacy, University of Mississippi


2019–Present:  Faculty Advisor, Ole Miss Vietnamese American Student Association (Ole VASA) 


2019–2020:  Member, AACP New Investigator Awards Review Committee


2019–2020:  Vice Chair, Research and Graduate Affairs Committee, School of Pharmacy, University of Mississippi


2017–2021:  Founder and Director, Science, Technology, Engineering and Math Summer Research Experience for Undergraduates (STEMS REU) Program, University of Mississippi


2016–2019:  Member, Research and Graduate Affairs Committee, School of Pharmacy, University of Mississippi

Other Experiences

2022:  Poster Judge, MALTO Medicinal Chemistry and Pharmacognosy Meeting-in-Miniature


2022:  Poster Abstract Reviewer, 2022 AACP Annual Meeting


2022:  National Research Mentoring Network (NRMN)'s Grant Writing Coaching Program    


2021:  Poster Abstract Reviewer, Virtual Pharmacy Education: The 2021 AACP Annual Meeting


2021:  Judge, Regional Science Fair for Elementary Schools


2018:  NIGMS Mentoring Workshop for New Faculty in Organic and Biological Chemistry


2018:  NSF Chemistry Early Career Investigator Workshop


2018:  Poster Judge, MALTO Medicinal Chemistry and Pharmacognosy Meeting-in-Miniature


2018–Present:  Member, Experimental Therapeutics Group, UMMC Cancer Center and Research Institute


2018:  Poster Judge, Southeastern Undergraduate Research Conference (SURC)


2017:  Poster Judge, MALTO Medicinal Chemistry and Pharmacognosy Meeting-in-Miniature


2015:  NIH Training in Neurotherapeutics Discovery and Development for Academic Scientists

Professional Memberships

The Rho Chi Society (the Academic Honor Society in Pharmacy)


American Association of Colleges of Pharmacy


American Chemical Society (Divisions of Medicinal Chemistry and Organic Chemistry)

Patents

University of Mississippi


13)  Le, H. V.; Hossain, M. I. U.S. Patent Application 17,597,550 (filed January 11, 2022). L-γ-methyleneglutamine compounds and methods of use


Northwestern University


12)  Silverman, R. B.; Takaya, K.; Le, H. V.; Juncosa, J. I. India Patent IN 372532 (July 23, 2021). (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as GABA aminotransferase inactivators for the treatment of epilepsy, addiction, and hepatocellular carcinoma


11)  Silverman, R. B.; Takaya, K.; Le, H. V.; Juncosa, J. I. Australia Patent AU 2016334396 (July 22, 2021). (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as GABA aminotransferase inactivators for the treatment of epilepsy, addiction, and hepatocellular carcinoma 


10)  Silverman, R. B.; Juncosa, J.; Le, H. V.; Takaya, K. Israel Patent IL 258516 (April 1, 2021). (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, a highly potent GABA aminotransferase inactivator for the treatment of epilepsy, addiction, and hepatocellular carcinoma 


9)  Silverman, R. B.; Juncosa, J.; Le, H. V.; Takaya, K. Japan Patent JP 6841821 (February 22, 2021). (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as GABA aminotransferase inactivators for the treatment of epilepsy, addiction, and hepatocellular carcinoma 


8)  Silverman, R. B.; Juncosa, J.; Le, H. V.; Takaya, K. China Patent ZL 2016800590699 (February 12, 2021). (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, a highly potent GABA aminotransferase inactivator for the treatment of epilepsy, addiction, and hepatocellular carcinoma 


7)  Silverman, R. B.; Le, H. V.; Hawker, D. D. U.S. Patent 10,800,753 B2 (October 13, 2020). Tetrahydrothiophene-based GABA aminotransferase inactivators and analogs thereof for treating neurological disorders 


6)  Silverman, R. B.; Le, H. V.; McLeod, R. L.; Hawker, D. D. U.S. Patent 10,632,088 B2 (April 28, 2020). Inactivators of Toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria 


5)  Juncosa, J.; Le, H. V.; Silverman, R. B.; Takaya, K., Columbia Patent Certificado Numero 37025 (April 17, 2020). Compuestos derivados del ácido (S)-3-amino-4-(difluorometilenil)ciclopent-1-eno-1-carboxílico como inhibidores de GABA aminotransferase 


4)  Silverman, R. B.; Le, H. V.; Hawker, D. D. U.S. Patent 10,189,807 B2 (January 29, 2019). Tetrahydrothiophene-based GABA aminotransferase inactivators 


3)  Silverman, R. B.; Takaya, K.; Le, H. V.; Juncosa, J. I. U.S. Patent 9,993,449 B2 (June 12, 2018). (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as GABA aminotransferase inactivators for the treatment of epilepsy, addiction, and hepatocellular carcinoma 


2)  Silverman, R. B.; Hawker, D. D.; Le, H. V. U.S. Patent 9,856,231 B2 (January 2, 2018). Tetrahydrothiophene-based GABA aminotransferase inactivators 


1)  Silverman, R. B.; Takaya, K.; Le, H. V.; Juncosa, J. I. U.S. Patent 9,670,141 B2 (June 6, 2017). (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as GABA aminotransferase inactivators for the treatment of epilepsy, addiction, and hepatocellular carcinoma

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